THE FORMATION OF N10-FORMYLFOLIC ACID FROM FORMAMIDINOGLUTARIC ACID AND FOLIC ACID
نویسندگان
چکیده
منابع مشابه
Formation of 10-formylfolic acid, a potent inhibitor of dihydrofolate reductase, in rat liver slices incubated with folic acid.
During investigation of folate polyglutamate biosynthesis in rat liver slices utilizing [2-(14)C]folic acid, a folate compound that behaved like a polyglutamate form in the Sephadex G-15 gel filtration system was found to accumulate. Subsequent chromatographic, spectral, chemical, and enzymic studies have indicated that the compound formed in liver slices incubated with [(14)C]folic acid with a...
متن کاملFormimino transfer from formamidinoglutaric acid to tetrahydrofolic acid.
The enzymatic formation of PO-CHOeFA’ from FA with FAG as the specific formyl donor and with a soluble liver extract as the source of enzymes has been described in the preceding paper (1). The specific l-carbon acceptor appeared to be FAHd which functioned catalytically. When FAG and substrate amounts of FAHd were incubated with enzyme and the reaction mixture acidified, ACF could be detected a...
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چکیده ندارد.
15 صفحه اولThe Biosynthesis of Folic Acid. Iii. Enzymatic Formation of Dihydrofolic Acid from Dihydropteroic Acid and of Tetrahydropteroylpolyglutamic Acid Compounds from Tetrahydrofolic Acid.
Although dihydrofolic acid can be formed enzymatically, in the presence of adenosine triphosphate, from 2-amino4-hydroxy-6hydroxymethyldihydropteridine and p-aminobenzoylglutamic acid (3, 4), Brown, Weisman, and Molnar (4) have postulated that dihydropteroic acid, instead of p-aminobenzoylglutamic acid, is the normal intermediate in dihydrofolate synthesis in Escherichia coli. They have present...
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نقص لوله عصبی یکی از ناهنجاریهای مادرزادی مهم و شایع می باشد که شیوع آن بیش از ۵/ ۴ در ۱۰۰۰ تولد زنده است. اتیولوژی و پاتوژنز بیماری هنوز ناشناخته است. مطالعات اخیر بر روی حیوانات نشان می دهد که این ناهنجاری ممکن است، ناشی از متابولیسم غیر طبیعی هموسیستئین باشد. در مطالعات اخیر مشخص شده است که پیشگیری از نقص لوله عصبی (NTD) بوسیله اسیدفولیک مؤثر می باشد.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70720-5